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glybenclamide gly  (Novus Biologicals)


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    Structured Review

    Novus Biologicals glybenclamide gly
    (A) Time-dependent changes in intracellular K + concentrations in macrophages infected with virulent EIAV or vaccine EIAV. Here NC refers to negative control and LPS+Nigericin (Nig) means positive control. (B) Time-dependent changes in intracellular Ca 2+ concentrations in macrophages infected with virulent EIAV or vaccine EIAV. (C) Time-dependent changes in intracellular K + concentrations in macrophages pre-treated with P2X7 (R) -specific siRNA for 6 h, and then infected with virulent EIAV or vaccine EIAV. (D-E) Evaluation IL-1β in supernatants of 293T cells co-transfected with virulent- env or vaccine- env in the presence of increasing doses of the K + efflux inhibitor <t>(Glybenclamide,</t> 50 µM,100 µM) (D) and KCl (50 µM,100 µM) (E) (Tat served as a negative control) (* P < 0.05, ** P < 0.01). All data are mean of 2 independent experiments (n = 2 per group).
    Glybenclamide Gly, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 93/100, based on 10 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/glybenclamide+gly/Glybenclamide+(NLRP3+Inhibitor)/pmc12187018-143-0-5
    Average 93 stars, based on 10 article reviews
    glybenclamide gly - by Bioz Stars, 2026-09
    93/100 stars

    Images

    1) Product Images from "Env from EIAV vaccine delicately regulates NLRP3 activation via attenuating NLRP3-NEK7 interaction"

    Article Title: Env from EIAV vaccine delicately regulates NLRP3 activation via attenuating NLRP3-NEK7 interaction

    Journal: PLOS Pathogens

    doi: 10.1371/journal.ppat.1012772

    (A) Time-dependent changes in intracellular K + concentrations in macrophages infected with virulent EIAV or vaccine EIAV. Here NC refers to negative control and LPS+Nigericin (Nig) means positive control. (B) Time-dependent changes in intracellular Ca 2+ concentrations in macrophages infected with virulent EIAV or vaccine EIAV. (C) Time-dependent changes in intracellular K + concentrations in macrophages pre-treated with P2X7 (R) -specific siRNA for 6 h, and then infected with virulent EIAV or vaccine EIAV. (D-E) Evaluation IL-1β in supernatants of 293T cells co-transfected with virulent- env or vaccine- env in the presence of increasing doses of the K + efflux inhibitor (Glybenclamide, 50 µM,100 µM) (D) and KCl (50 µM,100 µM) (E) (Tat served as a negative control) (* P < 0.05, ** P < 0.01). All data are mean of 2 independent experiments (n = 2 per group).
    Figure Legend Snippet: (A) Time-dependent changes in intracellular K + concentrations in macrophages infected with virulent EIAV or vaccine EIAV. Here NC refers to negative control and LPS+Nigericin (Nig) means positive control. (B) Time-dependent changes in intracellular Ca 2+ concentrations in macrophages infected with virulent EIAV or vaccine EIAV. (C) Time-dependent changes in intracellular K + concentrations in macrophages pre-treated with P2X7 (R) -specific siRNA for 6 h, and then infected with virulent EIAV or vaccine EIAV. (D-E) Evaluation IL-1β in supernatants of 293T cells co-transfected with virulent- env or vaccine- env in the presence of increasing doses of the K + efflux inhibitor (Glybenclamide, 50 µM,100 µM) (D) and KCl (50 µM,100 µM) (E) (Tat served as a negative control) (* P < 0.05, ** P < 0.01). All data are mean of 2 independent experiments (n = 2 per group).

    Techniques Used: Infection, Negative Control, Positive Control, Transfection

    Related Articles

    Infection:

    Article Title: Env from EIAV vaccine delicately regulates NLRP3 activation via attenuating NLRP3-NEK7 interaction
    Article Snippet: Glybenclamide (Gly) was purchased from Novus Biologicals (NBP2-30141, USA).

    Article Title: Env from EIAV vaccine delicately regulates NLRP3 activation via attenuating NLRP3-NEK7 interaction.
    Article Snippet: Glybenclamide (Gly) was purchased from Novus Biologicals (NBP2-30141, USA).

    Article Title: Env from EIAV vaccine delicately regulates NLRP3 activation via attenuating NLRP3-NEK7 interaction
    Article Snippet: Glybenclamide (Gly) was purchased from Novus Biologicals (NBP2-30141, USA).

    Negative Control:

    Article Title: Env from EIAV vaccine delicately regulates NLRP3 activation via attenuating NLRP3-NEK7 interaction
    Article Snippet: Glybenclamide (Gly) was purchased from Novus Biologicals (NBP2-30141, USA).

    Article Title: Env from EIAV vaccine delicately regulates NLRP3 activation via attenuating NLRP3-NEK7 interaction.
    Article Snippet: Glybenclamide (Gly) was purchased from Novus Biologicals (NBP2-30141, USA).

    Article Title: Env from EIAV vaccine delicately regulates NLRP3 activation via attenuating NLRP3-NEK7 interaction
    Article Snippet: Glybenclamide (Gly) was purchased from Novus Biologicals (NBP2-30141, USA).

    Positive Control:

    Article Title: Env from EIAV vaccine delicately regulates NLRP3 activation via attenuating NLRP3-NEK7 interaction
    Article Snippet: Glybenclamide (Gly) was purchased from Novus Biologicals (NBP2-30141, USA).

    Article Title: Env from EIAV vaccine delicately regulates NLRP3 activation via attenuating NLRP3-NEK7 interaction.
    Article Snippet: Glybenclamide (Gly) was purchased from Novus Biologicals (NBP2-30141, USA).

    Article Title: Env from EIAV vaccine delicately regulates NLRP3 activation via attenuating NLRP3-NEK7 interaction
    Article Snippet: Glybenclamide (Gly) was purchased from Novus Biologicals (NBP2-30141, USA).

    Transfection:

    Article Title: Env from EIAV vaccine delicately regulates NLRP3 activation via attenuating NLRP3-NEK7 interaction
    Article Snippet: Glybenclamide (Gly) was purchased from Novus Biologicals (NBP2-30141, USA).

    Article Title: Env from EIAV vaccine delicately regulates NLRP3 activation via attenuating NLRP3-NEK7 interaction.
    Article Snippet: Glybenclamide (Gly) was purchased from Novus Biologicals (NBP2-30141, USA).

    Article Title: Env from EIAV vaccine delicately regulates NLRP3 activation via attenuating NLRP3-NEK7 interaction
    Article Snippet: Glybenclamide (Gly) was purchased from Novus Biologicals (NBP2-30141, USA).



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    Recombinant PrgI triggers the NAIP/NLRC4 inflammasome, whereas flagellin activates the NAIP/NLRC4 and the NLRP3 inflammasome in THP-1 cells. Parental wild-type THP-1 ( A , B , and D ), NLRC4 KO (A and B), NAIP KO ( C ), or NLRP3 KO (D) cells were transfected with PrgI or flagellin (A–D) or stimulated with LPS+ nigericin (B–D) in the presence of NLRP3 inhibitors MCC950 (B and C) or <t>glybenclamide</t> (B). ASC speck formation (B–D) and IL-1β (A) and IL-18 (A–D) release were determined at 4 h poststimulation. Mean with SD of at least three individual experiments (two replicates/experiment) is displayed. Statistical analysis was performed using two-way ANOVA followed by a Bonferroni posttest. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
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    glybenclamide gly  (Novus Biologicals)
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    (A) Time-dependent changes in intracellular K + concentrations in macrophages infected with virulent EIAV or vaccine EIAV. Here NC refers to negative control and LPS+Nigericin (Nig) means positive control. (B) Time-dependent changes in intracellular Ca 2+ concentrations in macrophages infected with virulent EIAV or vaccine EIAV. (C) Time-dependent changes in intracellular K + concentrations in macrophages pre-treated with P2X7 (R) -specific siRNA for 6 h, and then infected with virulent EIAV or vaccine EIAV. (D-E) Evaluation IL-1β in supernatants of 293T cells co-transfected with virulent- env or vaccine- env in the presence of increasing doses of the K + efflux inhibitor <t>(Glybenclamide,</t> 50 µM,100 µM) (D) and KCl (50 µM,100 µM) (E) (Tat served as a negative control) (* P < 0.05, ** P < 0.01). All data are mean of 2 independent experiments (n = 2 per group).
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    (A) Time-dependent changes in intracellular K + concentrations in macrophages infected with virulent EIAV or vaccine EIAV. Here NC refers to negative control and LPS+Nigericin (Nig) means positive control. (B) Time-dependent changes in intracellular Ca 2+ concentrations in macrophages infected with virulent EIAV or vaccine EIAV. (C) Time-dependent changes in intracellular K + concentrations in macrophages pre-treated with P2X7 (R) -specific siRNA for 6 h, and then infected with virulent EIAV or vaccine EIAV. (D-E) Evaluation IL-1β in supernatants of 293T cells co-transfected with virulent- env or vaccine- env in the presence of increasing doses of the K + efflux inhibitor <t>(Glybenclamide,</t> 50 µM,100 µM) (D) and KCl (50 µM,100 µM) (E) (Tat served as a negative control) (* P < 0.05, ** P < 0.01). All data are mean of 2 independent experiments (n = 2 per group).
    Gly, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    (A) Time-dependent changes in intracellular K + concentrations in macrophages infected with virulent EIAV or vaccine EIAV. Here NC refers to negative control and LPS+Nigericin (Nig) means positive control. (B) Time-dependent changes in intracellular Ca 2+ concentrations in macrophages infected with virulent EIAV or vaccine EIAV. (C) Time-dependent changes in intracellular K + concentrations in macrophages pre-treated with P2X7 (R) -specific siRNA for 6 h, and then infected with virulent EIAV or vaccine EIAV. (D-E) Evaluation IL-1β in supernatants of 293T cells co-transfected with virulent- env or vaccine- env in the presence of increasing doses of the K + efflux inhibitor <t>(Glybenclamide,</t> 50 µM,100 µM) (D) and KCl (50 µM,100 µM) (E) (Tat served as a negative control) (* P < 0.05, ** P < 0.01). All data are mean of 2 independent experiments (n = 2 per group).
    Glybenclamide (Gly, supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    h n glyburide 3 h gly 50 ci mmol  (Revvity)
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    (A) Time-dependent changes in intracellular K + concentrations in macrophages infected with virulent EIAV or vaccine EIAV. Here NC refers to negative control and LPS+Nigericin (Nig) means positive control. (B) Time-dependent changes in intracellular Ca 2+ concentrations in macrophages infected with virulent EIAV or vaccine EIAV. (C) Time-dependent changes in intracellular K + concentrations in macrophages pre-treated with P2X7 (R) -specific siRNA for 6 h, and then infected with virulent EIAV or vaccine EIAV. (D-E) Evaluation IL-1β in supernatants of 293T cells co-transfected with virulent- env or vaccine- env in the presence of increasing doses of the K + efflux inhibitor <t>(Glybenclamide,</t> 50 µM,100 µM) (D) and KCl (50 µM,100 µM) (E) (Tat served as a negative control) (* P < 0.05, ** P < 0.01). All data are mean of 2 independent experiments (n = 2 per group).
    H N Glyburide 3 H Gly 50 Ci Mmol, supplied by Revvity, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    (A) Time-dependent changes in intracellular K + concentrations in macrophages infected with virulent EIAV or vaccine EIAV. Here NC refers to negative control and LPS+Nigericin (Nig) means positive control. (B) Time-dependent changes in intracellular Ca 2+ concentrations in macrophages infected with virulent EIAV or vaccine EIAV. (C) Time-dependent changes in intracellular K + concentrations in macrophages pre-treated with P2X7 (R) -specific siRNA for 6 h, and then infected with virulent EIAV or vaccine EIAV. (D-E) Evaluation IL-1β in supernatants of 293T cells co-transfected with virulent- env or vaccine- env in the presence of increasing doses of the K + efflux inhibitor <t>(Glybenclamide,</t> 50 µM,100 µM) (D) and KCl (50 µM,100 µM) (E) (Tat served as a negative control) (* P < 0.05, ** P < 0.01). All data are mean of 2 independent experiments (n = 2 per group).
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    Image Search Results


    Recombinant PrgI triggers the NAIP/NLRC4 inflammasome, whereas flagellin activates the NAIP/NLRC4 and the NLRP3 inflammasome in THP-1 cells. Parental wild-type THP-1 ( A , B , and D ), NLRC4 KO (A and B), NAIP KO ( C ), or NLRP3 KO (D) cells were transfected with PrgI or flagellin (A–D) or stimulated with LPS+ nigericin (B–D) in the presence of NLRP3 inhibitors MCC950 (B and C) or glybenclamide (B). ASC speck formation (B–D) and IL-1β (A) and IL-18 (A–D) release were determined at 4 h poststimulation. Mean with SD of at least three individual experiments (two replicates/experiment) is displayed. Statistical analysis was performed using two-way ANOVA followed by a Bonferroni posttest. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.

    Journal: The Journal of Immunology Author Choice

    Article Title: Salmonella Flagellin Activates NAIP/NLRC4 and Canonical NLRP3 Inflammasomes in Human Macrophages

    doi: 10.4049/jimmunol.2000382

    Figure Lengend Snippet: Recombinant PrgI triggers the NAIP/NLRC4 inflammasome, whereas flagellin activates the NAIP/NLRC4 and the NLRP3 inflammasome in THP-1 cells. Parental wild-type THP-1 ( A , B , and D ), NLRC4 KO (A and B), NAIP KO ( C ), or NLRP3 KO (D) cells were transfected with PrgI or flagellin (A–D) or stimulated with LPS+ nigericin (B–D) in the presence of NLRP3 inhibitors MCC950 (B and C) or glybenclamide (B). ASC speck formation (B–D) and IL-1β (A) and IL-18 (A–D) release were determined at 4 h poststimulation. Mean with SD of at least three individual experiments (two replicates/experiment) is displayed. Statistical analysis was performed using two-way ANOVA followed by a Bonferroni posttest. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.

    Article Snippet: Native ultrapure S. Typhimurium flagellin (tlrl-epstfla-5), ultrapure Bacillus subtilis flagellin (tlrl-pbsfla), the NLRP3 inhibitors MCC950 (inh-mcc), and glybenclamide (tlrl-gly) were purchased from InvivoGen.

    Techniques: Recombinant, Transfection

    (A) Time-dependent changes in intracellular K + concentrations in macrophages infected with virulent EIAV or vaccine EIAV. Here NC refers to negative control and LPS+Nigericin (Nig) means positive control. (B) Time-dependent changes in intracellular Ca 2+ concentrations in macrophages infected with virulent EIAV or vaccine EIAV. (C) Time-dependent changes in intracellular K + concentrations in macrophages pre-treated with P2X7 (R) -specific siRNA for 6 h, and then infected with virulent EIAV or vaccine EIAV. (D-E) Evaluation IL-1β in supernatants of 293T cells co-transfected with virulent- env or vaccine- env in the presence of increasing doses of the K + efflux inhibitor (Glybenclamide, 50 µM,100 µM) (D) and KCl (50 µM,100 µM) (E) (Tat served as a negative control) (* P < 0.05, ** P < 0.01). All data are mean of 2 independent experiments (n = 2 per group).

    Journal: PLOS Pathogens

    Article Title: Env from EIAV vaccine delicately regulates NLRP3 activation via attenuating NLRP3-NEK7 interaction

    doi: 10.1371/journal.ppat.1012772

    Figure Lengend Snippet: (A) Time-dependent changes in intracellular K + concentrations in macrophages infected with virulent EIAV or vaccine EIAV. Here NC refers to negative control and LPS+Nigericin (Nig) means positive control. (B) Time-dependent changes in intracellular Ca 2+ concentrations in macrophages infected with virulent EIAV or vaccine EIAV. (C) Time-dependent changes in intracellular K + concentrations in macrophages pre-treated with P2X7 (R) -specific siRNA for 6 h, and then infected with virulent EIAV or vaccine EIAV. (D-E) Evaluation IL-1β in supernatants of 293T cells co-transfected with virulent- env or vaccine- env in the presence of increasing doses of the K + efflux inhibitor (Glybenclamide, 50 µM,100 µM) (D) and KCl (50 µM,100 µM) (E) (Tat served as a negative control) (* P < 0.05, ** P < 0.01). All data are mean of 2 independent experiments (n = 2 per group).

    Article Snippet: Glybenclamide (Gly) was purchased from Novus Biologicals (NBP2-30141, USA).

    Techniques: Infection, Negative Control, Positive Control, Transfection